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There were no deaths or significant adverse situations related to drug therapy in clinical trials involving 800 non-pregnant Females who gained METROGEL-VAGINAL.

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Metronidazole has proven evidence of carcinogenic activity in many scientific studies involving Long-term, oral administration in mice and rats although not in research involving hamsters.

Oral metronidazole continues to be claimed to potentiate the anticoagulant impact of warfarin and other coumarin anticoagulants, causing a prolongation of prothrombin time.